Deutsch
IllnessResistance to viral infections, differential diagnosis
Summary
Short information
Comprehensive differential diagnostic panel for Resistance to viral infections comprising 10 curated genes according to the clinical signs
ID
VP8797
Number of genes
10
Accredited laboratory test
Examined sequence length
0,0 kb (Core-/Core-canditate-Genes)
15,6 kb (Extended panel: incl. additional genes)
15,6 kb (Extended panel: incl. additional genes)
Analysis Duration
on request
Test material
- EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications
NGS +
[Sanger]
Gene panel
Selected genes
| Name | Exon Length (bp) | OMIM-G | Referenz-Seq. | Heredity |
|---|---|---|---|---|
| CCR5 | 1059 | NM_000579.4 | AD, AR | |
| CXCL12 | 282 | NM_000609.7 | n.k. | |
| CXCR1 | 1053 | NM_000634.3 | n.k. | |
| DDX58 | 2778 | NM_014314.4 | n.k. | |
| FUT2 | 1032 | NM_000511.6 | AR | |
| KIR3DL1 | 1335 | NM_013289.3 | n.k. | |
| LDLR | 2583 | NM_000527.5 | AD | |
| MX1 | 1989 | NM_001144925.2 | n.k. | |
| TLR3 | 2715 | NM_003265.3 | n.k. | |
| TNF | 702 | NM_000594.4 | Ass |
Informations about the disease
Clinical Comment
Viruses are a problem for man, represent one of the central pre-occupations of the immune system; higher eukaryotes have evolved broadly active mechanisms to sense viruses + suppress proliferation; mechanisms are ancient or new to discriminate self from non-self
Synonyms
- Allelic: Asthma, susceptibility to (TNF)
- Allelic: Dementia, vascular, susceptibility to (TNF)
- Allelic: Diabetes mellitus, insulin-dependent, 22 (CCR5)
- Allelic: Encephalopathy, acute, infection-induced, herpes-specific, susceptibility to, 2 (TLR3)
- Allelic: H-deficient red cell Bombay phenotype, Dig (FUT2)
- Allelic: Hypercholesterolemia, familial, 1 (LDLR)
- Allelic: LDL cholesterol level QTL2 (LDLR)
- Allelic: Malaria, cerebral, susceptibility to (TNF)
- Allelic: Migraine without aura, susceptibility to (TNF)
- Allelic: Septic shock, susceptibility to (TNF)
- Allelic: Singleton-Merten syndrome 2 (DDX58)
- Allelic: Vitamin B12 plasma level QTL1 (FUT2)
- AIDS, delayed/rapid progression to (KIR3DL1)
- AIDS, resistance to (CXCL12)
- AIDS, slow progression to (CXCR1)
- Anti-TNFa treatments increase the risk of reactivation in chronic HBV infection (TNF)
- HIV infection, susceptibility/resistance to (CCR5)
- HIV1 infection, resistance to (TLR3)
- Hepatitis C virus + others enter cells via LDLR-mediated endocytosis (LDLR)
- Hepatitis C virus, resistance to (CCR5)
- Interferon-induced antiviral activity, e.g. subacute sclerosing panencephalitisis (MX1)
- Norwalk virus infection, resistance to (FUT2)
- RNA virus eradication: paramyxoviruses, influenza virus, Japanese encephalitis virus (DDX58)
- West nile virus, susceptibility to (CCR5)
Heredity, heredity patterns etc.
- AD
- AR
- Ass
- n.k.
OMIM-Ps
- Multiple OMIM-Ps
ICD10 Code
Bioinformatics and clinical interpretation
No text defined