Deutsch
IllnessVirus-Resistenz, Differentialdiagnose
Summary
Short information
Comprehensive differential diagnostic panel for Resistance to viral infections comprising 10 curated genes according to the clinical signs
ID
VP8797
Number of loci
| Loci type | Count |
|---|---|
| Gen | 10 |
Examined sequence length
0,0 kb (Core-/Core-canditate-Genes)
15,6 kb (Extended panel: incl. additional genes)
15,6 kb (Extended panel: incl. additional genes)
Analysis Duration
on request
Test material
- EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications
NGS +
[Sanger]
Loci panel
Gen
| Name | Exon Length (bp) | OMIM-G | Referenz-Seq. | Heredity |
|---|---|---|---|---|
| CCR5 | 1059 | NM_000579.4 | AD, AR | |
| CXCL12 | 282 | NM_000609.7 | n.k. | |
| CXCR1 | 1053 | NM_000634.3 | n.k. | |
| DDX58 | 2778 | NM_014314.4 | n.k. | |
| FUT2 | 1032 | NM_000511.6 | AR | |
| KIR3DL1 | 1335 | NM_013289.3 | n.k. | |
| LDLR | 2583 | NM_000527.5 | AD | |
| MX1 | 1989 | NM_001144925.2 | n.k. | |
| TLR3 | 2715 | NM_003265.3 | n.k. | |
| TNF | 702 | NM_000594.4 | Ass |
Informations about the disease
Clinical Comment
Viruses are a problem for man, represent one of the central pre-occupations of the immune system; higher eukaryotes have evolved broadly active mechanisms to sense viruses + suppress proliferation; mechanisms are ancient or new to discriminate self from non-self
Synonyms
- Allelic: Asthma, susceptibility to (TNF)
- Allelic: Dementia, vascular, susceptibility to (TNF)
- Allelic: Diabetes mellitus, insulin-dependent, 22 (CCR5)
- Allelic: Encephalopathy, acute, infection-induced, herpes-specific, susceptibility to, 2 (TLR3)
- Allelic: H-deficient red cell Bombay phenotype, Dig (FUT2)
- Allelic: Hypercholesterolemia, familial, 1 (LDLR)
- Allelic: LDL cholesterol level QTL2 (LDLR)
- Allelic: Malaria, cerebral, susceptibility to (TNF)
- Allelic: Migraine without aura, susceptibility to (TNF)
- Allelic: Septic shock, susceptibility to (TNF)
- Allelic: Singleton-Merten syndrome 2 (DDX58)
- Allelic: Vitamin B12 plasma level QTL1 (FUT2)
- AIDS, delayed/rapid progression to (KIR3DL1)
- AIDS, resistance to (CXCL12)
- AIDS, slow progression to (CXCR1)
- Anti-TNFa treatments increase the risk of reactivation in chronic HBV infection (TNF)
- HIV infection, susceptibility/resistance to (CCR5)
- HIV1 infection, resistance to (TLR3)
- Hepatitis C virus + others enter cells via LDLR-mediated endocytosis (LDLR)
- Hepatitis C virus, resistance to (CCR5)
- Interferon-induced antiviral activity, e.g. subacute sclerosing panencephalitisis (MX1)
- Norwalk virus infection, resistance to (FUT2)
- RNA virus eradication: paramyxoviruses, influenza virus, Japanese encephalitis virus (DDX58)
- West nile virus, susceptibility to (CCR5)
Heredity, heredity patterns etc.
- AD
- AR
- Ass
- n.k.
OMIM-Ps
- Multiple OMIM-Ps
ICD10 Code
Bioinformatics and clinical interpretation
No text defined