Deutsch
IllnessDiabetes mellitus, type 2, susceptibility
Summary
Short information
Comprehensive panel for Diabetes mellitus, type 2, susceptibility comprising 3 and altogether 27 curated genes according to the clinical signs
ID
DP6675
Number of genes
15
Accredited laboratory test
Examined sequence length
4,2 kb (Core-/Core-canditate-Genes)
25,0 kb (Extended panel: incl. additional genes)
25,0 kb (Extended panel: incl. additional genes)
Analysis Duration
on request
Test material
- EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications
NGS + SNP
[Sanger]
Gene panel
Selected genes
| Name | Exon Length (bp) | OMIM-G | Referenz-Seq. | Heredity |
|---|---|---|---|---|
| GPD2 | 2184 | NM_000408.5 | AD, Sus | |
| MTNR1B | 1089 | NM_005959.5 | AD, Sus | |
| PDX1 | 852 | NM_000209.4 | AD | |
| ABCC8 | 4746 | NM_000352.6 | AD, AR | |
| GCK | 1398 | NM_000162.5 | Sus | |
| HMGA1 | 291 | NM_002131.4 | AD, Sus | |
| HNF1A | 1896 | NM_000545.8 | AD | |
| HNF1B | 1674 | NM_000458.4 | AD, Sus | |
| HNF4A | 1359 | NM_175914.4 | AD, Sus | |
| IGF2BP2 | 1671 | NM_001007225.3 | AD, Sus | |
| IRS1 | 3729 | NM_005544.3 | AD | |
| KCNJ11 | 1173 | NM_000525.4 | AD, Sus | |
| NEUROD1 | 1071 | NM_002500.5 | AD, Sus | |
| PPARG | 1518 | NM_015869.5 | AD, Sus | |
| RETN | 327 | NM_001193374.2 | AD |
Informations about the disease
Clinical Comment
Diabetes type 2 usually occurs in adulthood; overweight + lack of exercise predispose; in many cases preventable by lifestyle changes
Synonyms
- Alias: Diabetes mellitus, type 2, susceptibility to
- Allelic: Diabetes mellitus, transient neonatal 3 (KCNJ11)
- Allelic: Hyperinsulinemic hypoglycemia, familial, 2 (KCNJ11)
- Allelic: Hypoinsulinemic hypoglycemia with hemihypertrophy (AKT2)
- Diabetes mellitus, noninsulin-dependent (HNF4A)
- Diabetes mellitus, noninsulin-dependent, susceptibility to (IGF2BP2, RETN)
- Diabetes mellitus, type 2, susceptibility to (KCNJ11)
- Diabetes mellitus, type II (AKT2)
- Diabetes, permanent neonatal 2, with/-out neurologic features (KCNJ11)
- Diabetes, type 2, susceptibility to (GPD2, MTNR1B, PDX1, TCFL2)
- Fanconi renotubular syndrome 4, with maturity-onset diabetes of the young (HNF4A)
- Growth retardation, developmental delay, facial dysmorphism (FTO)
- MODY, type I (HNF4A)
- Maturity-onset diabetes of the young, type 13 (KCNJ11)
- Obesity, susceptibility to, BMIQ1 (FTO)
- Renal cysts + diabetes syndrome (HNF1B)
- Type 2 diabetes mellitus (HNF1B)
- Type 2 diabetes mellitus, susceptibility to (NEUROD1, IRS1, HMGA1)
Heredity, heredity patterns etc.
- AD
- AR
- Sus
OMIM-Ps
- Multiple OMIM-Ps
ICD10 Code
Bioinformatics and clinical interpretation
No text defined